OPINIÃO

OPINIÃO: Tratamento do COV-19, o circo demagógico de Bolsonaro e o depoimento esclarecedor de uma médica

Gilson Dantas

Brasília

quarta-feira 17 de fevereiro| Edição do dia

[Imagem: ceara.gov.br]

[Essa é uma opinião do autor, e não representa a posição do MRT sobre o tema]

O desastre irreparável das mortes pela pandemia faz parte da conta de um regime político [Bolsonaro] que tem destruído postos de trabalho, concentrado renda, arrancado direitos trabalhistas elementares, aumentado o estoque de pobreza, privatizado o país e, por fim, procurar acabar com o serviço público e o SUS.

Também tem sido o governo Bolsonaro, que tem feito a maior e mais irresponsável demagogia com a hidroxicloroquina, como forma de encobrir sua política sanitária desastrosa e desviar a atenção, hipocritamente, para o tratamento da COV-19.

Por que hipocritamente? Porque jamais teve qualquer política real contra a pandemia, muito menos na questão do tratamento, o qual, de parte do governo, nunca foi além do circo da automedicação, da ema e, ao mesmo tempo, medidas reacionárias contra o povo trabalhador.

Ao final, um governo altamente funcional para o capital financeiro, incluindo a Big Pharma, , a qual agradece o fervor populista de Bolsonaro em queimar os dois medicamentos antiCOVID-19 que não interessam à Big Pharma, precisamente porque são demonstradamente superiores, clinicamente, àquilo que o mercado dos medicamentos patenteados tem a oferecer contra o COV-19.

Durante todo esse tempo, vivemos um determinado processo: de um lado, acumulavam-se crescentes evidências em favor de certos medicamentos baratos e não-patenteáveis por conta da sua capacidade de, clinicamente, derrubar a carga viral e salvar vidas; ao mesmo tempo, a grande mídia [e ao seu lado, a burocracia médica, tendo como alter ego econômico a Big Pharma] escalava em iniciativas e incessante luta contra esse tipo de tratamento. Zero cobertura científica integral.

E ainda por cima, a demagogia reacionária de Bolsonaro; de tal forma que o resultado ficou sendo o de que a ciência respeitável é apenas a veiculada pela OMS/grande mídia. Mesmo que as evidências científicas se acumulem em vários países, em várias línguas, e por parte dos mais diferentes cientistas, nada disso é aceito como evidência científica, ou apenas é aceito se prestigiar medicamentos patenteados e caros dos barões das farmacêuticas [Big Pharma]. Enquanto isso, a bandeira do tratamento ia sendo emporcalhada por Bolsonaro e a hidroxicloroquina ficava malfadadamente conhecida [equivocadamente] como a “droga do Bolsonaro”.

Nesse meio tempo, muitos médicos que estudam com afinco, foram acumulando conhecimentos - e ao mesmo tempo recebendo uma carga de preconceito dos seus pares mais conservadores – e foram dando ao público suas opiniões científicas, que propunham o debate baseado em evidências clínicas; o debate sem dogmas ou desqualificação política binária [na qual quem argumenta pela hidroxicloroquina ou a ivermectina, para citar apenas dois medicamentos não patenteados, é automaticamente cancelado, e lhe colocam um sinal de igualdade com o reacionário Bolsonaro e seu circo demagógico em torno da “cloroquina”].

Essa disjuntiva foi tensionada durante todo o ano passado e certamente cobrou muitas mortes no marco do mantra de que não há tratamento para o COV-19 [muitas mortes poderiam, segundo a Dra Tess Lawrie, ter sido salvas pelo pronto tratamento aos primeiros sintomas do COV-19; ver aqui]. Enquanto isso Bolsonaro impulsionava as mortes com sua política social e sanitária.

Ensaios e demonstrações clínicas vieram de todos os lados e, ao mesmo tempo, mais de dez estudos clínicos de alto nível [RTC] apareceram. O rei perdeu sua última vestimenta.

Mas não para a big mídia e a alta burocracia médica, que - diante da força das evidências clínicas - radicalizaram, e estão agora a pressionar para que os Conselhos punam médicos que prescrevam tais medicamentos [um non sense que cassa o mais elementar direito do médico de salvar vidas com medicamentos off label reposicionados] [1].

O impasse continua: crescem as evidências, escala a polarização, recrudescem os ataques dos que decidiram, dogmaticamente, que não há tratamento para o COV-19.

No entanto, no meio médico despontaram médicas como a Dra Lucy Kerr, no Brasil, na Inglaterra a Dra Tess Lawrie assim como vários outros profissionais e agora, como se verá nessa nota, a infectologista Dra Roberta Dantas, do Hospital Universitário do Rio Grande do Norte.

Esta última, recentemente deu palestra para médicos, na Associação Médica do RN, em 11/2/2021, com o título Evidências científicas do tratamento precoce do COV-19, que tomamos a liberdade de divulgar por aqui, em vídeo editado [para que tenha menor duração] e que pode ser visto abaixo.

Por que recomendamos enfaticamente esse vídeo para todos aqueles que querem pensar com a própria cabeça a questão do tratamento n do vírus COV-19?

Pela capacidade de argumentação da médica [autora de outra exposição sobre a ivermectina no COV-19 que pode ser vista aqui ] e que possui a rara habilidade – a partir dos seus estudos independentes da Big Pharma desde o começo da pandemia, de resumir dados e elementos essenciais para a compreensão deste tema e que não podem ser, em absoluto, encontrados na grande imprensa.

A grande mídia absolutamente não deu voz a essa médica [nem à Dra L. Kerr, que tem sido atacada sumariamente sem que sua voz seja diretamente ouvida]. E isso por razões mais ou menos óbvias: destoando da Big Pharma, ela foi investigar, sem a peia do dogma, se existe ciência detrás daquelas drogas indesejáveis para a grande indústria farmacêutica.

E encontrou farta evidência clínica [ver tabela a seguir].

IVERMECTINA PARA O COVID-19

Encontrou, portanto, material científico, mundo afora, que consolida, clinicamente, o uso da ivermectina [também há material sobre a hidroxicloroquina] no tratamento nos primeiros sintomas da COV-19.

Como a sua fala é autoexplicativa, detalhadamente esclarecedora da questão do tratamento com medicamentos como a ivermectina, e também sobre outros elementos da pandemia, passamos a palavra à Dra Roberta Dantas.

Desnecessário lembrar que, ao divulgá-la, não endossamos opiniões de quaisquer médicos [não sabemos se é o caso dela] que, em nome do tratamento, teçam quaisquer comentários favoráveis a um regime, Bolsonaro, que com sua empulhação em torno da sua “cloroquina” tem feito mais contra o tratamento do que qualquer um, e promovido mais mortes e miséria social do que a pandemia em si.

Com a palavra a Doutora.

[Observação – Como se pode ver pelo título desta nota, ela não pretende se ocupar da pandemia em geral, nem de suas contradições ou dos nefastos problemas derivados da sua gestão pelo capitalismo; se prende apenas a um desses problemas: o tratamento. Não é artigo de conjuntura política nacional ou internacional ou programático; aliás, do ponto de vista do programa político para sairmos dessa crise, evidentemente o debate sobre o tratamento é um deles e não o menos importante, na nossa perspectiva de salvar vidas, evitando a UTI. Ao mesmo tempo, para o mais profundo acompanhamento político da situação da pandemia no nosso país, recomendamos a leitura dos editoriais do Esquerda Diário e, em especial este recente documento internacional aqui ].

[Alerta – Não tome medicamentos sem informar-se com seu médico de confiança]

[Este artigo não representa integralmente a opinião do MRT, mas apenas a deste autor]

NOTAS 1:

[1] O uso off label é o uso de drogas farmacêuticas que não seguem as indicações homologadas para aquele fármaco. Quando um medicamento é aprovado para uma determinada indicação isso não implica que esta seja a única possível, e que o medicamento só possa ser usado para ela. Outras indicações podem estar sendo ou vir a ser estudadas. Estudos concluídos ou realizados após a aprovação inicial podem, por exemplo, ampliar o uso do medicamento para [...] outra doença. Quando um medicamento é comercializado e existem possíveis indicações ainda não aprovadas, pode ocorrer de um médico querer prescrever o medicamento para o seu paciente. Podem também seguir situações de um médico querer tratar pacientes que tenham certa condição que, por analogia com outra semelhante, ou por base fisiopatológica, ele acredite possam vir a se beneficiar de um determinado medicamento não aprovado para ela. Wiki.

[2] Currículo da Dra Roberta Dantas: http://lattes.cnpq.br/4274357206157641

NOTAS 2:
A seguir reunimos um determinado número, básico, de referências científicas que apontam positivamente para o uso clínico e antiviral da ivermectina na doença do COV-19:

[1] Oxford’s PRINCIPLE Trial: Bringing Ivermectin Directly into the Developed World in the Battle Against COVID-19 23/1/2021 https://trialsitenews.com/oxfords-principle-trial-bringing-ivermectin-directly-into-the-developed-world-in-the-battle-against-covid-19-2/ “The University of Oxford soon kicks “the PRINCIPLE Trial” into a higher gear now, in what they consider a pathbreaking “high-quality trial” of Ivermectin, a generic drug already evidencing significant efficacy in over two dozen clinical trials around the world, according to some researchers. The UK government also backs this pivotal study via the Department of Health and Social Care. Searching for early-onset, home-based ambulatory treatments for COVID-19, the PRINCIPLE Trial seeks to meet a gap in research in the world’s richest nations to date. Nearly all of the taxpayer-financed research-based expenditures of governments in the US, UK and Europe, for example, have gone into vaccines, novel monoclonal antibodies, and novel therapeutics, with an emphasis on treating severely ill patients. Ivermectin, hailed as the “wonder drug” or “the People’s medicine” for COVID-19, gains growing attention worldwide made more widely available, frankly, partly due to TrialSite’s consistent chronicling of these trials around the world since the original University of Monash breakthrough.[...] On the other hand, that Oxford is the first major center to embrace this important generic drug is truly game-changing and demonstrates the leadership position of that research institution again”.

[2] O livro do Dr G Dantas sobre o tratamento da doença do COV-19 pode ser solicitado - sem ônus - através do email [email protected], mencionado neste artigo: https://www.esquerdadiario.com.br/Coronavirus-medico-lanca-livro-sobre-tratamento-da-doenca

[3] Tess Lawrie: Ivermectin reduces the risk of death from COVID-19 – a rapid review and meta-analysis in support of the recommendation of the Front Line COVID-19 Critical Care Alliance. 3 January 2021. Evidence-based Medicine Consultancy Ltd. Bath.

[4] Tess Lawrie to Boris Johnson. A letter to Mr. Boris Johnson from UK scientist Dr. Tess Lawrie calling on him to start saving lives with Ivermectin. Health Rising 2021. Forums. Health News

[5] Database of all ivermectin COVID-19 studies. 55 studies, 21 peer reviewed, 35 with results comparing treatment and control groups. Submit updates/corrections below. FLCCC provides treatment recommendations.

[6] Ivermectin is effective for COVID-19: real-time meta analysis of 35 studies - https://ivmmeta.com/ 100% of the 35 studies to date report positive effects. Early treatment is more successful, with an estimated reduction of 84% in the effect measured using a random effects meta-analysis, RR 0.16 [0.08-0.33]. Prophylactic use also shows.

[7] Chamie-Quintero et al., Preprint, doi:10.2139/ssrn.3765018 (Preprint) Sharp Reductions in COVID-19 Case Fatalities and Excess Deaths in Peru in Close Time Conjunction, State-By-State, with Ivermectin Treatments Analysis of ivermectin usage within states in Peru showing sharp reductions in COVID-19 deaths corresponding to the usage of ivermectin treatment. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3765018 21-1-2021— “ These sharp major reductions in COVID-19 mortality following IVM treatment thus occurred in each of Peru’s states, with such especially sharp reductions in close time conjunction with IVM treatments in each of the nine states of operation MOT.”

[8] Heidary et al., The Journal of Antibiotics, 73, 593–602, doi:10.1038/s41429-020-0336-z (Review) (Peer Reviewed) https://www.nature.com/articles/s41429-020-0336-z Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen Review of the antimicrobial, antiviral, and anti-cancer properties of ivermectin. Antiviral effects have been reported for Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki For.. “In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting”.

[9] Mody et al., Communications Biology, doi:10.1038/s42003-020-01577-x (Peer Reviewed) (In Vitro) in vitro Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents Computational molecular modeling screening and in vitro analysis for inhibitory effects on SARS-CoV-2 specific 3CLpro enzyme, showing that ivermectin blocked more than 85% of 3CLpro activity of SARS-CoV-2. Antiviral activity of ivermectin. https://www.nature.com/articles/s42003-020-01577-x “In summary, these molecules [inclui a ivermectina] could be useful to develop highly specific therapeutically viable drugs to inhibit the SARS-CoV-2 replication either alone or in combination with drugs specific for other SARS-CoV-2 viral targets.”

[10] Prof Andrew Hill: See Whipple T. Ivermectin: Tests show cheap drug may reduce Covid-19 death toll. The TImes 2021 Jan 4. https://www.thetimes.co.uk/article/ivermectin-tests-show-cheap-drug-may-...

[11] Hill et al., Research Square, doi:10.21203/rs.3.rs-148845/v1 (Preprint) (meta analysis) meta-analysis Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection Meta analysis of 18 ivermectin RCTs with 2,282 patients showing faster viral clearance (dose and duration dependent), improved clinical recovery, and lower hospitalization and mortality. In six RCTs of moderate or severe infection, there .. ” This meta-analysis investigated ivermectin in 18 randomized clinical trials (2282 patients) identified through systematic searches of PUBMED, EMBASE, MedRxiv and trial registries. Ivermectin was associated with reduced inflammatory markers (C-Reactive Protein, d-dimer and ferritin) and faster viral clearance by PCR. Viral clearance was treatment dose- and duration-dependent. In six randomized trials of moderate or severe infection, there was a 75% reduction in mortality (Relative Risk=0.25 [95%CI 0.12-0.52]; p=0.0002); 14/650 (2.1%) deaths on ivermectin; 57/597 (9.5%) deaths in controls) with favorable clinical recovery and reduced hospitalization”. https://www.researchsquare.com/article/rs-148845/v1

[12] Paul Marik: The I-MASK+ protocol will revolutionize the treatment of COVID-19. The FLCCC Alliance press conference in Houston, Texas, Dec 4, 2020 , Front Line COVID-19 Critical Care Alliance.

[13] US Senate to the NIH. https://www.hsgac.senate.gov/imo/media/doc/40-317_Comm.%20Homeland%20Sec...

[14] Raad et al., ChiCTR2000033627 (Preprint) In vivo use of ivermectin (IVR) for treatment for corona virus infected patients (COVID-19): a randomized controlled Trial https://c19ivermectin.com/raad.html RCT in Lebanon showing significantly lower viral load at day 3, and lower hospitalization.

[15] Asghar et al., NCT04392713 (Preprint) Efficacy of Ivermectin in COVID-19 https://clinicaltrials.gov/ct2/show/NCT04392713 RCT with 103 patients in Pakistan comparing ivermectin and CQ, showing significantly lower PCR+ at day 7 with ivermectin.

[16] Kory et al., Frontiers in Pharmacology, doi:10.3389/fphar.2021.643369 (Review) (Peer Reviewed) review Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19 https://osf.io/wx3zn/?fbclid=IwAR1D8zI_SzOtaFAOG840QYFfdtvjcNxtd38-ej-hG_uj_RBIbkKYwCHnUbQ Meta analysis of ivermectin clinical studies and natural experiments where ivermectin has been widely used, showing efficacy of ivermectin in prophylaxis and treatment of COVID-19.” Although it is now standard practice for trials data from pré-print servers to immediately influence therapeutic practices during the pandemic, given the controversial therapeutics adopted as a result of this practice, the FLCCC argues that it is imperative that our major national and international health care agencies devote the necessary resources to more quickly validate these studies and confirm the major, positive epidemiological impacts that have been recorded when ivermectin is widely distributed among populations with a high incidence of COVID 19 infections”.

[17] Okumus et al., NCT04646109 (Preprint) Ivermectin for Severe COVID-19 Management https://clinicaltrials.gov/ct2/show/NCT04646109

[18] Ravikirti et al., medRxiv, doi:10.1101/2021.01.05.21249310 (Preprint) death, ?88.7%, p=0.12 Ivermectin as a potential treatment for mild to moderate COVID-19: A double blind randomized placebo-controlled Trial https://www.medrxiv.org/content/10.1101/2021.01.05.21249310v1 - “Conclusion There was no difference in the primary outcome i.e. negative RT-PCR status on day 6 of admission with the use of ivermectin. However, a significantly higher proportion of patients were discharged alive from the hospital when they received ivermectin”.

[19] Babalola et al., medRxiv, doi:10.1101/2021.01.05.21249131 (Preprint) viral+, ? Ivermectin shows clinical benefits in mild to moderate Covid19 disease: A randomised controlled double blind dose response study in Lagos https://www.medrxiv.org/content/10.1101/2021.01.05.21249131v1 “Conclusions 12 mg IV regime may have superior efficacy. IV should be considered for use in clinical management of SARS-Cov-2, and may find applications in community prophylaxis in high-risk áreas”. “CONCLUSIONS: Ivermectin use is associated with reduced duration of febrile illness in COVID-19 in outpatient setting, thus potentially saving precious lives, reducing direct load on healthcare facilities and preventing high cost of management in a community setting”.

[20] Hussain et al., International Journal of Molecular and Immuno Oncology, doi:10.25259/IJMIO_30_2020 (Peer Reviewed) Outcome of ivermectin and doxycycline in cancer patients with COVID-19: A positive experience in Bangladesh - “The World Health Organization estimated that the period of this viral shedding is up to 9 days and 20 days for the patients with mild symptoms and for those who are hospitalized, respectively.[1] We report data of eight SARSCoV-2-infected cancer patients who were treated with ivermectin and doxycycline combination and recovered in 6 days only. In addition, our patients remained non-infectious to other people in the hospital as the successive two PCR tests were negative”. https://covid19.cdmx.gob.mx/storage/app/media/Articulos/OutcomeofivermectinanddoxycyclineincancerpatientswithCOVID-19_ApositiveexperienceinBangladesh.pdf Small case study of ivermectin + doxycycline with 8 cancer patients, with all patients becoming PCR- by day 6 when tested again.

[21] Chaccour et al., EClinicalMedicine, doi:10.1016/j.eclinm.2020.100720 (preprint 12/7) (Peer Reviewed) The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial - https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30464-8/fulltext Tiny RCT for early treatment of mild COVID-19 in low risk patients, with 12 400mcg/kg single dose ivermectin patients and 12 control patients, showing significantly faster viral load reduction and symptom improvement with ivermectin. “Among patients with non-severe COVID-19 and no risk factors for severe disease receiving a single 400 mcg/kg dose of ivermectin within 72 h of fever or cough onset there was no difference in the proportion of PCR positives. There was however a marked reduction of self-reported anosmia/hyposmia, a reduction of cough and a tendency to lower viral loads and lower IgG titers which warrants assessment in larger trials”.

[22] Ahmed et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.11.191 (Peer Reviewed) A five day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness” - There were no severe adverse drug events recorded in the study. A 5-day course of ivermectin was found to be safe and effective in treating adult patients with mild COVID-19. Larger trials will be needed to confirm these preliminary findings”.

[23] Chamie, J. (News) The effect of using ivermectin to control COVID-19 in Chiapas https://c19ivermectin.com/chamie.html After starting to distribute ivermectin in drug kits in July, the Mexican state of Chiapas has seen a dramatic divergence from other states with much lower mortality [1, 2].

[24] Alonso et al., (Preprint) https://c19ivermectin.com/ Observational study in Argentina showing significantly lower mortality in the 60 days after adopting ivermectin compared to the 60 days before,

[25] Bernigaud et al., Annals of Dermatology and Venereology, doi:10.1016/j.annder.2020.09.231 (Peer Reviewed) Ivermectin benefit: from scabies to COVID-19, an example of serendipity https://c19ivermectin.com/bernigaud.html

[26] Hellwig et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106248 (Peer Reviewed) A COVID-19 Prophylaxis? Lower incidence associated with prophylactic administration of Ivermectin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698683/ “ It is suggested that ivermectin be evaluated for potential off-label prophylactic use in certain cases to help bridge the time until a safe and effective vaccine becomes available.”

[27] Heidary, Fatemeh; Gharebaghi, Reza (2020-09). Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen. The Journal of Antibiotics, 73 (9): 593-602. http://www.nature.com/articles/s41429-020-0336-z

[28] Crump A. Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations. J Antibiot. 2017;70:495–505. https://dx.doi.org/10.1038 /ja.2017.11

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[30] Tay, M. Y., Fraser, J. E., et al. (2013). Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin. Antiviral research, 99(3), 301–306. https://doi.org/10.1016/j.antiviral.2013.06.002

[31] Mastrangelo, E., Pezzullo, M., et al. (2012). Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. The Journal of antimicrobial chemotherapy, 67(8), 1884–1894. https://doi.org/10.1093/jac/dks147

[32] Yang, S., Atkinson, S. C., et al. (2020). The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer. Antiviral research, 177, 104760. https://doi.org/10.1016/j.antiviral.2020.104760

[33] Lundberg, L., Pinkham, C., et al. (2013). Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication. Antiviral research, 100(3), 662–672. https://doi.org/10.1016/j.antiviral.2013.10.004

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[35] Lee, Y. J., & Lee, C. (2016). Ivermectin inhibits porcine reproductive and respiratory syndrome virus in cultured porcine alveolar macrophages. Archives of virology, 161(2), 257–268. https://doi.org/10.1007/s00705-015-2653-2

[36] Caly et al., The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral Research, Vol. 178, June 2020, 104787. https://doi.org/10.1016/j.antiviral.2020.104787

[37] Jans, D. A., & Wagstaff, K. M. (2020). Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?. Cells, 9(9), 2100. https://doi.org/10.3390/cells9092100

[38] Jans, D. A., & Wagstaff, K. M. (2020). The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?. Biochemical and biophysical research communications, S0006-291X(20)31959-8. Advance online publication. https://doi.org/10.1016/j.bbrc.2020.10.042

[39] Peña‐Silva R. et al., Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID‐19, 17 July 2020 https://doi.org/10.1111/bcp.14476

[40] Momekov et al., Ivermectin as a potential COVID-19 treatment from the pharmacokinetic point of view: antiviral levels are not likely attainable with known dosing regimens, Journal Biotechnology & Biotechnological Equipment, 05 Jun 2020.

[41] Bray et al. (2020-06). Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors’ responses. Antiviral Research. https://dx.doi.org/10.1016 /j.antiviral.2020.104805

[42] Inclusión de la ivermectina en la primera línea de acción terapéutica para COVID-19. Se reporta una muy significativa disminución de la Tasa de Letalidad con su uso. http://dx.doi.org/10.13140/RG.2.2.34689.48482/4

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[44] https://www.argentina.gob.ar/noticias/un-estudio-demuestra-la-respuesta-antiviral-de-la-ivermectina-en-pacientes-con-covid-19

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[53] ChangjieLv et al., Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo, Antiviral Research, Volume 159, November 2018, Pages 55-62. https://doi.org/10.1016/j.antiviral.2018.09.010

[54] Therapeutic use of ivermectin against nuclear viruses in all animals: Nguyen et al., Ivermectin blocks the nuclear location signal of parvoviruses, Aquaculture, Vol. 420/1, 15/01/14, Pg. 288-294. https://doi.org/10.1016/j.aquaculture.2013.11.022

[55] Scheim, David, Ivermectin for COVID-19 Treatment: Clinical Response at Quasi-Threshold Doses Via Hypothesized Alleviation of CD147-Mediated Vascular Occlusion (June 26, 2020). SSRN: https://ssrn.com/abstract=3636557

[56] O’Donovan, S. M., Eby, H., et al. (2020). Identification of new drug treatments to combat COVID19: A signature-based approach using iLINCS. Research square, rs.3.rs-25643. https://doi.org/10.21203/rs.3.rs-25643/v1

[57] https://www.trialsitenews.com/medincell-continues-its-investigational-pursuit-of-ivermectin-targeting-covid-19-patients/

[58] Rajter et al., Use of Ivermectin is Associated with Lower Mortality in Hospitalized Patients in COVID19, medRxiv. 2020 https://doi.org/10.1101/2020.06.06.20124461

[59] https://www.cardioinfantil.org/recados-unidad-sintesis-transferencia/ivermectina-y-covid-19/

[60] Gorial et al., Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management, preprint.
[61]https://clinicaltrials.gov/ct2/show/study/NCT04343092?term=Ivermectine&draw=2&rank=5

[62] "Evaluación del efecto antiviral del fármaco ivermectina contra SARS-CoV-2” https://www.argentina.gob.ar/noticias/un-estudio-demuestra-la-respuesta-antiviral-de-la-ivermectina-en-pacientes-con-covid-19 Instituto de Investigaciones de Enfermedades Tropicales de la Sede regional Orán de la Universidad Nacional de Salta (UNSa), Laboratorio de Farmacología del Centro de Investigación Veterinaria de Tandil (CIVETAN), Universidad Nacional de Quilmes; del Hospital Juan P. Garrahan, y del Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno” (CEMIC), e integrantes del Laboratorio ELEA-Phoenix,

[63] http://www.civetan-conicet.gob.ar/cientificos-del-civetan-comprueban-la-actividad-antiviral-del-farmaco-ivermectina-en-pacientes-en-estadio-temprano-de-la-enfermedad-por-sars-cov-2/

[63] Elgazzar, A., Hany, B., et al., Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic, 13 November 2020, Research Square preprint, https://doi.org/10.21203/rs.3.rs-100956/v1

[64] McCullough, PA, Kelly, R. et al., Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection, July 2020, The American Journal of Medicine 134(1) https://doi.org/10.1016/j.amjmed.2020.07.003

[65] Carvallo, H., Hirsch R. et al., Study of the Efficacy and Safety of Topical Ivermectin + Iota-Carrageenan in the Prophylaxis against COVID-19 in Health Personnel, November 17, 2020, Journal of Biomedical Research and Clinical Investigation, Volume 2, Issue 1.1007m, ISSN:2633-8653, https://doi.org/10.31546/2633-8653.1007

[66] http://pharmabaires.com/1767-salta-y-corrientes-adoptan-ivermectina-en-sus-protocolos-covid.html

[67] Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology"; Bioresource Technoogy 100: 4012-4016.

[68] Ikeda, H; H. Kotaki & S. Omura 1989 "Genetic studies of avermectin biosynthesis in Streptomyces avermitilis"; Journal of Bactriology 169(12): 5615–5621.

[69] https://megalabs.global/peru-comienza-la-produccion-masiva-de-ivermectina/

[70] https://andina.pe/agencia/noticia-coronavirus-arequipa-entrega-primer-lote-ivermectina-producido-la-region-802855.aspx

[71] https://www.las2orillas.co/ivermectina-la-formula-contra-el-covid-que-en-cali-esta-funcionado/

[72] https://www.efe.com/efe/america/sociedad/cali-y-otras-ciudades-colombianas-apuestan-a-la-ivermectina-contra-el-covid-19/20000013-4293282

[73] https://www.trialsitenews.com/goa-game-changer-indian-states-health-authority-approves-distributes-ivermectin-doxycycline-to-treat-covid-19-as-prophylaxis/

[74] https://www.trialsitenews.com/goa-game-changer-indian-states-health-authority-approves-distributes-ivermectin-doxycycline-to-treat-covid-19-as-prophylaxis/

[75] https://www.infobae.com/america/tendencias-america/2020/06/15/cientificos-israelies-creen-que-un-medicamento-antiparasitario-podria-ser-prometedor-contra-el-covid-19/

[76] https://www.trialsitenews.com/university-of-kentucky-embraces-ivermectin-other-experimental-medications-in-pick-the-winner-covid-19-trial/

[77]https://www.reddit.com/r/ivermectin/comments/hjxchk/new_preprint_dramatically_better_response_for_ivm/

[78] https://www.infobae.com/salud/2020/07/02/con-el-protocolo-solo-tuvimos-un-fallecido-por-covid-19-como-es-el-tratamiento-que-aplica-un-hospital-bonaerense/

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[80]https://www.isglobal.org/documents/10179/7648746/Ivermectine_Table_With_Studies_Using_800_or_more.pdf/

[81] Smit M, Ochomo E, et al., Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial, The Lancet Infectious Diseases, March 27, 2018, ISSN: 1473-3099, Vol: 18, Issue: 6, Page: 615-626 DOI: https://doi.org/10.1016/S1473-3099(18)30163-4

[82] Guzzo CA, Furtek CI, et al. Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. J Clin Pharmacol. 2002 Oct;42(10):1122-33. doi: 10.1177/009127002401382731. PMID: 12362927.

[83]https://www.reddit.com/r/COVID19/comments/hk75iz/ivermectin_for_covid19_treatment_clinical/

[84] https://www.infobae.com/salud/ciencia/2020/09/25/los-detalles-del-estudio-con-ivermectina-para-uso-humano-que-demostro-reducir-la-carga-viral-y-la-contagiosidad-en-pacientes-con-covid-19/

[85] FDA contra a ivermectina: The FDA’s Center for Veterinary Medicine, FDA Letter to Stakeholders: Do Not Use Ivermectin Intended for Animals as Treatment for COVID-19 in Humans, April 10, 2020. Em espanhol: https://www.fda.gov/animal-veterinary/product-safety-information/carta-de-la-fda-las-partes-interesadas-no-use-ivermectina-destinada-animales-como-tratamiento-para 80 https://www.isglobal.org/healthisglobal/-/custom-blog-portlet/questions-and-answers-about-ivermectin-and-covid-19/2877257/0

[86] Ogbuokiri et al. PO. Ivermectin levels in human breast milk. Eur J Clin Pharmacol. 1994;46:89-90. Letter. https://www.ncbi.nlm.nih.gov/pubmed/8005194

[87] Niaee et al., Research Square, doi:10.21203/rs.3.rs-109670/v1 (Preprint) Analysis of COVID-19 cases vs. widespread prophylactic use of ivermectin for parasitic infections showing significantly lower incidence of COVID-19 cases. https://www.researchsquare.com/article/rs-109670/v1 “ Ivermectin as an adjunct reduced the rate of mortality, low O2 duration, and duration of hospitalization in adult COVID 19 patients. The improvement of other clinical parameters showed that the ivermectin, with a wide margin of safety, had a high therapeutic effect on COVID-19”.
[88 ] Spoorthi et al., IAIM, 2020, 7:10, 177-182 (Peer Reviewed) Utility of Ivermectin and Doxycycline combination for the treatment of SARSCoV-2 https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-896543 100 patient prospective trial of ivermectin + doxycycline showing reduced time to symptom resolution and shorter hospital stay with treatment. “Our study supports the benefits of utilization of combination of Doxycycline and Ivermectin in mild to moderate COVID-19 infection in terms of early recovery based on the time for symptom resolution and the mean duration of hospital stay”

[89 ] Elgazzar et al., Research Square, doi:10.21203/rs.3.rs-100956/v2 (Preprint) Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic https://www.researchsquare.com/article/rs-100956/v2 ” Conclusion: Addition of Ivermectin to standard care is very effective drug for treatment of COVID-19 patients with significant reduction in mortality compared to Hydroxychloroquine plus standard treatment only. Early use of Ivermectin is very useful for controlling COVID 19 infections; prophylaxis and improving cytokines storm”.

[90] Cadegiani et al., medRxiv, doi:10.1101/2020.10.31.20223883 (Preprint) death, ? Early COVID-19 Therapy with Azithromycin Plus Nitazoxanide, Ivermectin or Hydroxychloroquine in Outpatient Settings Significantly Reduced Symptoms Compared to Known Outcomes in Untreated Patients https://www.medrxiv.org/content/10.1101/2020.10.31.20223883v1 Comparison of HCQ, nitazoxanide, and ivermectin showing similar effectiveness for overall clinical outcomes in COVID-19 when used before seven days of symptoms, and overwhelmingly superior compared to the untreated COVID-19 population, ev.. ” Early pharmacological approaches including azithromycin in combination with any of the options between nitazoxanide, ivermectin or optionally hydroxychloroquine should be considered for those diagnosed with COVID-19 presenting less than seven days of symptoms. Of the three drugs, we opted for nitazoxanide, due to more extensive demonstration of in vitro and in vivo antiviral activity, proven efficacy against other viruses in humans, and steadier safety profile”.

[91] Behera et al., medRxiv, doi:10.1101/2020.10.29.20222661v1 (Preprint) cases, ? Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: a matched case-control study https://www.medrxiv.org/content/10.1101/2020.10.29.20222661v1 Retrospective prophylaxis study for HCQ, ivermectin, and vitamin C with 372 healthcare workers, showing lower COVID-19 incidence for all treatments, with statistical significance reached for ivermectin. HCQ OR 0.56, p = 0.29 Ivermectin O.. - “Conclusion - Two-dose ivermectin prophylaxis at a dose of 300 μg/kg with a gap of 72 hours was associated 73% reduction of COVID-19 infection among healthcare workers for the following one-month. Further research is required before its large scale use”.

[92] Arévalo et al., bioRxiv, doi:10.1101/2020.11.02.363242 (Preprint) animal study - Ivermectin reduces coronavirus infection in vivo: a mouse experimental model https://pesquisa.bvsalud.org/portal/resource/pt/ppbiorxiv-363242

[93] Raja Bhattacharya, View ORCID ProfileSampurna Chowdhury - Pre exposure hydroxychloroquine prophylaxis for covid-19 in healthcare workers: a retrospective cohort - https://www.medrxiv.org/content/10.1101/2020.06.09.20116806v3.full - “CONCLUSIONS This study demonstrated that voluntary HCQ consumption as pre-exposure prophylaxis by HCWs is associated with a statistically significant reduction in risk of SARS-CoV-2”.

[94 ] Hashim et al., medRxiv, doi:10.1101/2020.10.26.20219345 (Preprint) death, ? Controlled randomized clinical trial on using Ivermectin with Doxycycline for treating COVID-19 patients in Baghdad, Iraq https://www.medrxiv.org/content/10.1101/2020.10.26.20219345v1 ” Conclusions Ivermectin with doxycycline reduced the time to recovery and the percentage of patients who progress to more advanced stage of disease; in addition, Ivermectin with doxycycline reduced mortality rate in severe patients from 22.72% to 0%; however, 18.2% of critically ill patients died with Ivermectin and doxycycline therapy. Taken together, the earlier administered Ivermectin with doxycycline, the higher rate of successful therapy

[95] Guerrero et al., Colombia Médica, doi:10.25100/cm.v51i4.4613 (Peer Reviewed) COVID-19: The Ivermectin African Enigma - Study of African Programme for Onchocerciasis Control (APOC) countries, which used ivermectin, with non-APOC countries in Africa, showing 28% lower mortality for APOC countries, https://colombiamedica.univalle.edu.co/index.php/comedica/article/view/4613 “Conclusions: The incidence in mortality rates and the number of cases is significantly lower among the APOC countries compared to non-APOC countries. That a mass public health preventive campaign against COVID-19 may have taken place, inadvertently, in some African countries with massive community ivermectin use is an attractive hypothesis. Additional studies are needed to confirm it”.

[96] Rajter et al., Chest, doi:10.1016/j.chest.2020.10.009 (Peer Reviewed) death, ? Use of Ivermectin is Associated with Lower Mortality in Hospitalized Patients with COVID-19 (ICON study) https://pubmed.ncbi.nlm.nih.gov/33065103/ ” Ivermectin treatment was associated with lower mortality during treatment of COVID-19, especially in patients with severe pulmonary involvement”. Retrospective 280 hospitalized patients showing lower mortality with ivermectin (13.3% vs 24.5%), propensity matched odds ratio OR 0.47 [0.22-0.99], p=0.045.

[97] Mahmud et al., Clinical Trial Results, NCT04523831 (Preprint) Clinical Trial of Ivermectin Plus Doxycycline for the Treatment of Confirmed Covid-19 Infection https://clinicaltrials.gov/ct2/show/results/NCT04523831?view=results RCT for ivermectin+doxycycline showing improvements in mortality, recovery, progression, and virological cure. There is no paper yet, results are reported on clinicaltrials.gov. 183 treatment and 180 control patients.

[98] Francés-Monerris et al., ChemRxiv, doi:10.26434/chemrxiv.12782258.v1 (Preprint) (Theory) Has Ivermectin Virus-Directed Effects against SARS-CoV-2? Rationalizing the Action of a Potential Multitarget Antiviral Agent https://chemrxiv.org/articles/preprint/Has_Ivermectin_Virus-Directed_Effects_against_SARS-CoV-2_Rationalizing_the_Action_of_a_Potential_Multitarget_Antiviral_Agent/12782258/1 “Hence, the wide spectrum of actions involving i) the interference with cell infection, ii) the inhibition of viral replication, and iii) elusion of the host immune system, could point to an unprecedented synergy between host- and virus-directed effects explaining the high anti-SARS-CoV-2 activity observed for this compound”.

[99] Khan et al., Archivos de Bronconeumología, doi:10.1016/j.arbres.2020.08.007 (Letter) Ivermectin treatment may improve the prognosis of patients with COVID-19 - https://www.archbronconeumol.org/es-ivermectin-treatment-may-improve-prognosis-articulo-S030028962030288X - “Therefore, given the urgent need to manage the COVID-19 patients with a safe, cheap and widely available drug, the present findings suggest that ivermectin can be considered as a first-line treatment for containing SARS-CoV-2 to prevent severe irreversible respiratory complications and community transmission. A multicenter, double-blind, drug-controlled study will strengthen our findings”.

[100] Leon Caly, Julian D Druce et al - The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro – “We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection with SARS-CoV-2 able to effect 5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans”.
“ - https://www.sciencedirect.com/science/article/pii/S0166354220302011

[101] Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal? - Review of ivermectin as a host-directed broad-spectrum antiviral agent for a range of viruses, including SARS-CoV-2. Cell culture experiments show robust antiviral action towards HIV-1, dengue virus (DENV), Zika virus, West Nile virus, V.. https://pubmed.ncbi.nlm.nih.gov/32942671/ - “This mini-review discusses the case for ivermectin as a host-directed broad-spectrum antiviral agent for a range of viruses, including SARS-CoV-2”. -

[102] Effects of Ivermectin-azithromycin-cholecalciferol combined therapy on COVID-19 infected patients: A proof of concept study https://www.alliedacademies.org/abstract/effects-of-ivermectinazithromycincholecalciferol-combined-therapy-on-covid19-infected-patients-a-proof-of-concept-study-14435.html
Small study with 28 patients treated with ivermectin + AZ + cholecalciferol and 7 control patients. All treated patients were PCR- at day 10 while all control patients remained PCR+. “This study found that the combination treatment might mitigate disease progression without significant adverse effects. Further studies are needed in order to extrapolate these findings to moderate and severe COVID-19”.

[103] Bhattacharya et al., Int. J. Scientific Research, doi:10.36106/ijsr/7232245 (Peer Reviewed) Observational Study on Clinical Features, Treatment and Outcome of COVID 19 in a tertiary care Centre in India- a retrospective case series - Retrospective 148 hospitalized patients showing triple therapy with ivermectin + atorvastatin + N-acetylcysteine resulted in a 1.35% case fatality rate which was well below the national average. ” Conclusions: Triple therapy with ivermectin + atorvastatin + N-acetylcysteine can be an useful adjunct to standard of care”. https://www.researchgate.net/publication/343660942_Observational_Study_on_Clinical_Features_Treatment_and_Outcome_of_COVID_19_in_a_tertiary_care_Centre_in_India-_a_retrospective_case_series

[104] Chang et al., ResearchGate (Preprint) Post-acute or prolonged COVID-19: ivermectin treatment for patients with persistent symptoms or post-acute symptoms Report on 33 patients with persistent or post-acute symptoms treated with ivermectin, showing a high rate of clinical improvement. “CONCLUSION: The result of the present study demonstrates that clinical improvement is observed in high percentage of patients with Persistent or Post-Acute Symptoms of COVID-19 who are treated with Ivermectin. Given the high number of patients with Persistent Symptoms and a favorable clinical response seen after receiving this specific treatment, we recommend that additional clinical studies be carried out on the use of Ivermectin and other drugs to reduce and eliminate the viral load in these cases”. https://www.researchgate.net/publication/344318845_POST ACUTE_OR_PROLONGED_COVID-19_IVERMECTIN_TREATMENT_FOR_PATIENTS_WITH_PERSISTENT_SYMPTOMS_OR_POST-ACUTE

[105] Chang et al., ResearchGate, doi:10.13140/RG.2.2.34561.48483/2 (Preprint) COVID-19: Post-exposure prophylaxis with ivermectin in contacts. At Homes, Places of Work, Nursing Homes, Prisons, and Others - “The inclusion of Acetylsalicylic Acid (ASA) or Aspirin in the PEP Schedule should be considered for men over 55 years of age and in persons with Increased Risk of developing
severe illness. Recommended dose is 1 tablet of 100 mg after lunch for 6 to 10 days.
Contacts should remain under observation in case they begin to show characteristic symptoms
of COVID-19, in which case they should move to therapeutic doses of Ivermectin”.
https://www.researchgate.net/publication/344781515_COVID-19_POST-EXPOSURE_PROPHYLAXIS_WITH_IVERMECTIN_IN_CONTACTS_At_Homes_Places_of_Work_Nursing_Homes_Prisons_and_Others

[106] Alam et al., Journal of Bangladesh College of Physicians and Surgeons, doi:10.3329/jbcps.v38i0.47512 (Peer Reviewed) A Case Series of 100 COVID-19 Positive Patients Treated with Combination of Ivermectin and Doxycycline “All patients tested negative and their symptoms improved within 72 hours. There were no noticeable side effects. Conclusion: Combination of Ivermectin and doxycycline was found to be very effective in viral clearance in mild and moderately sick COVID-19 patients. Medical societies and institutions should undertake larger multi center studies to validate and recommend this combination therapy to include in national guidelines”. Case study of 100 patients treated with ivermectin and doxycycline, with no ICU admission, deaths, or serious side effects reported. https://www.researchgate.net/publication/343305357_A_Case_Series_of_100_COVID-19_Positive_Patients_Treated_with_Combination_of_Ivermectin_and_Doxycycline

[107] Rahman et al., J. Bangladesh Coll. Phys. Surg. 38, 5-9, doi:10.3329/jbcps.v38i0 (Peer Reviewed) Comparison of Viral Clearance between Ivermectin with Doxycycline and Hydroxychloroquine with Azithromycin in COVID-19 Patients - “Conclusion: It appears Ivermectin and Doxycycline is safeand effective combination drug therapy in COVID- 19infected patients but need further extensive study to find out the scope of application on other groups of patients”. https://www.banglajol.info/index.php/JBCPS/article/view/47514

[108] Chowdhury et al., Research Square, doi:10.21203/rs.3.rs-38896/v1 (Preprint) A Randomized Trial of Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patients - “Conclusion The Ivermectin-Doxycycline combination showed a trend toward superiority to the Hydroxychloroquine-Azithromycin combination therapy in the case of patients with mild to moderate COVID19 disease, though the difference in time to becoming symptom-free and the difference in time to negative PCR was not statistically significant”. https://www.researchsquare.com/article/rs-38896/v1

[109] Gorial et al., medRxiv, doi:10.1101/2020.07.07.20145979 (Preprint) death, Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial) - “ConclusionsAdd-on use of IVM to HCQ and AZT had better effectiveness, shorter hospital stay, and relatively safe compared with controls. however, a larger prospective study with longer follow up may be needed to validate these results”. https://pesquisa.bvsalud.org/portal/resource/pt/ppmedrxiv-20145979

[110] Lehrer et al., In Vivo, 34:5, 3023-3026, doi:10.21873/invivo.12134 (Theory) Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2 https://www.x-mol.com/paper/1302073874220027904?recommendPaper=5812856 In silico analysis showing ivermectin docking which may interfere with the attachment of the spike to the human cell membrane.

[111] Rezai et al., IRCT20111224008507N3 (Preprint) Effectiveness of Ivermectin in the Treatment of Coronavirus Infection in Patients admitted to Educational Hospitals of Mazandaran in 2020 RCT in Iran showing shorter time to clinical recovery with Ivermectin. Results are from: [1] https://c19study.com/rezai.html

[112] Afsar et al., SSRN (Preprint) Ivermectin Use Associated with Reduced Duration of COVID-19 Febrile Illness in a Community Setting Small 95 patient study in Pakistan adding ivermectin to standard of care (HCQ+AZ) for outpatients with mild/moderate suspected COVID-19, showing faster resolution of fever with ivermectin. https://c19hcq.com/afsar.html

[113] Lacey Newlin - Could Ivermectin be an answer to both parasites and pandemics? https://www.hpj.com/ag_news/could-ivermectin-be-an-answer-to-both-parasites-and-pandemics/article_0b578c96-5529-11eb-b6bc-f78e273cbf37.html

[114]https://www.reddit.com/r/ivermectin/comments/l7iwld/ivermectin_to_save_belgium_belgium_20201222/

[115] Bangladesh: ivermectin shows promise in treating vírus - https://www.aa.com.tr/en/asia-pacific/bangladesh-ivermectin-shows-promise-in-treating-virus/2068885

[116] Ivermectin medicine to be used for Covid-19 treatment in Uttar Pradesh
https://www.knocksense.com/lucknow/ivermectin-medicine-to-be-used-for-covid-19-treatment-in-uttar-pradesh

[117] Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19): a structured summary of a study protocol for a randomized controlled Trial https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04813-1

[118] Un estudio demuestra la respuesta antiviral de la ivermectina en pacientes con COVID-19 - https://www.argentina.gob.ar/noticias/un-estudio-demuestra-la-respuesta-antiviral-de-la-ivermectina-en-pacientes-con-covid-19

[119] Crump, A., & Ōmura, S. (2011). Ivermectin, ’wonder drug’ from Japan: the human use perspective. Proceedings of the Japan Academy. Series B, Physical and biological sciences, 87(2), 13–28. https://doi.org/10.2183/pjab.87.13
[120] Geary T. G. (2005). Ivermectin 20 years on: maturation of a wonder drug. Trends in parasitology, 21(11), 530–532. https://doi.org/10.1016/j.pt.2005.08.014

[121] Belgian Virologist Proposes a Plan to Eradicate COVID-19 in 6 Weeks Using Ivermectin - Fev 2021 https://trialsitenews.com/belgian-virologist-proposes-a-plan-to-eradicate-covid-19-in-6-weeks-using-ivermectin/ “Referencing the meta-analysis from Dr. Tess Lawrie in the UK, the Belgian virologist shares that based on 15 randomized controlled trials and observational controlled trials, the ivermectin treatment reduces deaths by an average of 83% (95% Cl 65%-92%). He shares that based on the Dr. Lawrie meta-analysis, the drug also reduces the risk of deterioration by 53% (95% Cl 23%-71). Furthermore, Wathelet cites Lawrie that the drug used as prophylaxis given to health care workers or relatives can reduce the risk of infection by 88% (95% Cl 82%-92%). He aligns with America-based Front Line COVID-19 Critical Care Alliance (FLCCC) “

[122] Update on South African Doctors’ Legal Action to Make Ivermectin Available as Prescription for COVID-19 13-2-2021 - https://trialsitenews.com/update-on-south-african-doctors-legal-action-to-make-ivermectin-available-as-prescription-for-covid-19/ “The theme is similar in many nations around the world. Governments resist a well-known drug with an overall safe profile that appears to be able to help treat COVID-19 in democratic societies. The ostensible rationale is that the drug isn’t yet proven, and regulators have asked for randomized, controlled trials. Yet there have been dozens of these studies, some even funded by groups affiliated with the World Health Organization, and regulators still seem unimpressed. In this case in South Africa, the group of physicians merely don’t want to be labeled criminals when they are treating their patients off-label. That’s because the bureaucratic stage gates associated with Article 21 don’t make sense during a pandemic.
TrialSite suggests that it would appear that this looks increasingly not like a scientific or even business problem, but actually, a political and legal one as is becoming apparent in South Africa. Perhaps those involved with political organizing start mobilizing”.

[123] Randomized Double-Blinded Clinical Trial at Sheba Medical Center: Ivermectin Materially Reduces COVID-19 Viral Shedding 13/2/2021 https://trialsitenews.com/randomized-double-blinded-clinical-trial-at-sheba-medical-center-ivermectin-materially-reduces-covid-19-viral-shedding/ “A small but important randomized, double-blinded clinical trial sponsored by a top Israeli principal investigator and infectious disease physician embraced the use of ivermectin as a possible candidate to reduce viral shedding as well as lessen clinical deterioration for a targeted 100 early-onset, mild COVID-19 patients. The director of the Center for Geographic & Tropical Medicine at Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv, Professor Eli Schwartz, conducted this clinical trial starting in the summer. TrialSite spoke with Professor Schwartz in November, and he was still enrolling patients; however, he was recently able to conclude the study and report on the results on Vimeo. The study’s takeaway: ivermectin significantly reduces the viral shedding overall in patients with COVID-19. Moreover, while the patient sample wasn’t sufficiently sized, the data did reveal that the drug typically used to treat parasites can reduce infectivity duration”.

[124] Zambia Drug Regulator Embraces Ivermectin Research Program as COVID-19 Worsens in this Southern African Naion 11/2/2021 https://trialsitenews.com/zambia-drug-regulator-embraces-ivermectin-research-program-as-covid-19-worsens-in-this-southern-african-nation/ “Another African nation embraces an ivermectin research campaign as the second COVID-19 pandemic wave hits Africa far harder. As SARS-CoV-2 infections started to spread in Africa by the end of 2020—and the number of cases and deaths continue to grow—researchers now investigate the efficacy and safety of this drug as a low cost and widely available regiment to stave off COVID-19. An emerging trend in Africa, as recently South African’s regulatory agency adjusted its stance and accepted ivermectin for compassionate use (and embracing research), Zimbabwe regulators delve into the drug for research as a care option potential. A top researcher in Nigeria conducted an important ivermectin study targeting COVID-19 thanks to the support of that nation’s Vice President, while last summer TrialSite was in touch researchers in Tanzania—the University of Dodoma was considering ivermectin/COVID-19 clinical trial in collaboration with the National Institute for Medical Research in that eastern African nation. Now a health regulatory body in the southern African nation of Zambia launches clinical trials investigating the efficacy of ivermectin to treat and even prevent COVID-19. This occurs as a recent study reveals that appears to be an undercounting of COVID-19 related death there and potentially many other African countries.

[125] The Jerusalem Post Introduces the Sheba Medical Center-Sponsored Ivermectin Randomized, Controlled Double Blinded Findings By TrialSite Staff February 14, 2021 https://trialsitenews.com/the-jerusalem-post-introduces-the-sheba-medical-center-sponsored-ivermectin-randomized-controlled-double-blinded-findings/ This article puts forth the position from Prof. Schwartz, founder of the Center for Travel Medicine and Tropical Disease situated at the Sheba Medical Center in Tel Hashomer, that the existing generic, FDA-approved drug used commonly as a antiparasitic agent actually can reduce the duration of infection associated with SARS-CoV-2, the virus behind COVID-19”.

[126] iBeheraP, Patro BK, Singh AK, et al. Role of Ivermectin in the prevention of COVID-19 infection among health care workers in India. medRxiv 2020.https://doi.org/10.1101/2020.10.29.20222661

[127] Robin RC, Alam RF, Saber S, Bhiuyan E, Murshed R, Alam MT. A Case Series of 100 COVID19 Positive Patients Treated with Combination of Ivermectin and Doxycycline. Journal of Bangladesh College of Physicians and Surgeons. 2020:10-15.

[128] Shouman W. Use of Ivermectin as a Prophylactic Option in Asymptomatic Family Close Contact for Patient with COVID-19. Clinical Trials.gov. 2020. NCT04422561.

NOTA 3:
PEQUENA AMOSTRAGEM DOS VIDEOS [XX] SOBRE A IVERMECTINA MOSTRANDO SEU VALOR MÉDICO-CIENTÍFICO:

[1] Randomized Double Blind Trial IVM and Early COVID-19:
https://www.youtube.com/watch?v=u-4mNFH2dbU

[2] Ivermectin Immunosuppressive Effects in COVID-19:
https://www.youtube.com/watch?v=2KZSOkaqSNg&ab_channel=WhiteboardDoctor

[3] Second Interview With Pioneering Researcher Dr. Carvallo! https://www.youtube.com/watch?v=Ar-OaKEhsog

[4] IVM and Doxy in COVID-19 Patients with Cancer: https://www.youtube.com/watch?v=Djc3OW5BCFk

[5] IVM Early Outpatient Treatment: Randomized Trial: https://www.youtube.com/watch?v=W_oYKtn8jeg

[6] High Dose Ivermectin And COVID-19: https://www.youtube.com/watch?v=wsJPZPB93Qc

[7] IVM, IVM and Doxy, Versus Placebo For Hospitalized COVID-19: https://www.youtube.com/watch?v=z7rwWY371ac

[8] IVM and HCQ for mild, moderate, severe disease AND prophylaxis! https://www.youtube.com/watch?v=zE2RfRbUBIc

[9] IVM, HCQ, or Vitamin C Prophylaxis for COVID-19: https://www.youtube.com/watch?v=Z1TGzbr_RDo

[10] Four Different Mechanisms of Action Of IVM: https://www.youtube.com/watch?v=9bgcgiutrw8

[11] Ivermectin, Azithromycin, And Vitamin D Early Outpatient COVID-19: https://www.youtube.com/watch?v=_4UWnxUrE7I

[12] IDEA Trial (Ivermectin, Dexamethasone, Enoxaparin, Aspirin) Mild, Mod, Sever COVID: https://www.youtube.com/watch?v=hX14ol0FYHg

[13] Ivermectin to Treat Hospitalized Patients with COVID-19: https://www.youtube.com/watch?v=_UvZHJh_wdk

[14] Ivermectin Post-Exposure Prophylaxis: https://www.youtube.com/watch?v=nJyyISQg85M

[15] ICON Trial: https://www.youtube.com/watch?v=ryWcke_-Fjs&t=388s

[16] HCQ +/- Azithromycin Videos: RECOVERY Trial HCQ for COVID-19: https://www.youtube.com/watch?v=viF14-W_1MM

[17] Low Dose HCQ to treat COVID-19: https://www.youtube.com/watch?v=ihEkCddeLOA

[18] Outpatient use of HCQ for early COVID-19 https://www.youtube.com/watch?v=V0_PkRkq3p4

[19] HCQ and Azithromycin 3,737 patient in France https://www.youtube.com/watch?v=My8PY97ZuAI&t=1040s

[20] Henry Ford Hospital Study decreased mortality with HCQ and HCQ+Azithro: https://www.youtube.com/watch?v=FSEtu5VUJQA

[21] Zinc Videos (+/- HCQ/Azithro): Does Adding Zinc to Hydroxychloroquine Improve Outcomes? https://www.youtube.com/watch?v=cS9gj6sWxY8

[22] HCQ, Azithro versus HCQ, Azithro, and Zn in Hospitalized COVID: https://www.youtube.com/watch?v=sFAM97cW1jo

[23] Zinc, Hydroxychloroquine, and Azithromycin for early COVID-19 in outpatients: https://www.youtube.com/watch?v=4eR0oV0Yqwo

[24] Triple Therapy Zinc, Hydroxychloroquine, and Azithromcyin: https://www.youtube.com/watch?v=EwS3BajTFDY&t=1347s

[xx] Estes vídeos acima estão disponíveis no link: Review Of 18 Studies on Ivermectin and COVID-19: https://www.youtube.com/watch?v=NOpiMasSvSE

[25] IVERMECTINA 2021 - Dra Lucy Kerr atualiza dosagem correta na segunda onda - Fernando Beteti https://www.youtube.com/watch?v=f0hIPkL1oRo&t=786s

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Tratamento da doença do COVID-19   /    pandemia   /    Coronavírus   /    medicina do capital

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